1. The Distribution of Iron in Nature. - The basic physical chemical and biochemical properties of iron. - 2. Biochemical Evolution of the Heme-Type Enzymes. - 3. The Biological Significance of Iron-Containing Compounds. - 4. Distribution and Function of the Iron-Containing Complexes of the Human Organism. - Heme iron compounds. - Storage iron. - Transport iron. - Other non-heme iron compounds. - 5. Dietary Iron. - Iron intake. - 6. Iron Absorption. - Factors influencing iron absorption. - The control of iron absorption. - Measurement of iron absorption. - 7. Iron Transport. - Plasma iron. - Transferrin. - 8. Storage Iron. - Ferritin and hemosiderin. - Deposition and mobilization of iron. - Quantitative aspects of iron stores. - Clinical methods used for the estimation of available iron stores. - 9. Iron Loss and Iron Requirement. - Iron loss in women. - Iron requirements for newborns infants and children. - 10. Erythropoiesis. - 11. Hemoglobin Synthesis. - Biosynthesis of heme. - Biosynthesis of globin. - 12. Red Cell Destruction. - 13. Hemoglobin Catabolism. - 14. Ferrokinetics. - Survey. - Plasma iron clearance and plasma iron transport rate. - Incorporation of radioiron into the erythroblasts and reticulocytes. Iron utilization in the course of red cell production. Effective erythropoiesis. - Distribution of iron among the bone marrow liver and spleen. - 15. Erythrokinetics. - Red cell production. - Red cell destruction. - 16. Cytochemical Stains and Microscopy. - Siderocytes. - Sideroblasts. - Sideromacrophages. - 17. Electron Microscopic Investigations. - Ferritin. - Hemosiderin. - Erythrophagocytosis. - Iron transport. - Rhopheocytosis. - Sideroblasts and siderocytes. - 18. Iron Deficiency. - Incidence. - The clinical picture of iron deficiency. - Laboratory findings. - Ferrokinetics. - The diagnosis of iron deficiency. - Differential diagnosis of iron deficiency. - Etiology and pathogenesis of iron deficiency. - Therapy of iron deficiency. - Acute iron intoxication. - 19. Anemia of Infection. - Differential diagnosis. - Treatment. - 20. Anemia of Thermal Injury. - Development type and course of the anemia of thermal injury. - Therapy. - 21. Protein-Deficiency Anemia. - Vitamin E deficiency. - 22. Pernicious Anemia. - 23. Hemolytic Anemias. - 24. Refractory Hypochromic Anemias. - The sideroblastic anemias. - Pyridoxine-responsive anemias. - The disturbance of heme synthesis in thalassemia. - Pathological heme synthesis associated with lead and other toxic substances. - Sideroblastic anemias arising in connection with anti-tuberculous drugs. - Shahidi-Nathan-Diamond anemia. - Fanconi's anemia. - Genetically determined microcytic hypochromic anemias. - 25. Disturbed Iron Metabolism in Acute Radiation Injury. - 26. Iron Metabolism in Polycythemia Vera and Secondary Polycythemias. - 27. Iron Overload. - Idiopathic hemochromatosis (Iron storage disease). - Secondary hemochromatosis associated with cirrhosis of the liver. - Congenital atransferrinemia. - Congenital (familial) hypersiderosis. - Nutritional siderosis Bantu siderosis 360 Siderosis developing in refractory anemias associated with ineffective erythropoiesis. - Transfusional siderosis. - Renal hemosiderosis. - Idiopathic pulmonary hemosiderosis. - Goodpasture syndrome. - Author Index. Language: English